Presence of a bi-directional S phase-specific transcription regulatory element in the promoter shared by testis-specific TH2A and TH2B histone genes.

doi:10.1093/nar/19.1.93

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Article

Presence of a bi-directional S phase-specific transcription regulatory element in the promoter shared by testis-specific TH2A and TH2B histone genes.

Nucleic acids research - 11 Jan 1991

Huh N E, Hwang I W, Lim K, You K H, Chae C B

Abstract excerpt

During mammalian spermatogenesis, somatic histones are replaced by testis-specific variants. The synthesis of the variants occurs primarily in the germ cells undergoing meiosis in the absence of DNA replication. We have cloned the genes encoding rat somatic and testis-specific H2A (TH2A) histones. The two genes share 300 bp of 5' upstream region with respective H2B genes: somatic H2A with somatic H2B and...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA
DNA-Binding Proteins
Gene Expression
Genetic Variation
Histones
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Organ Specificity

Promoter Regions, Genetic

Rats

S Phase

Sequence Homology, Nucleic Acid

Testis

Source

Open in PubMed Open full text

Identifiers

PMID: 2011515
DOI: 10.1093/nar/19.1.93
PMCID: PMC333538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2011515-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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