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Article

Cardiac myosin binding protein C phosphorylation is cardioprotective.

Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 2006

Sadayappan Sakthivel, Osinska Hanna, Klevitsky Raisa, Lorenz John N, Sargent Michelle, Molkentin Jeffrey D, Seidman Christine E, Seidman Jonathan G, Robbins Jeffrey

Abstract excerpt

Cardiac myosin binding protein C (cMyBP-C) has three phosphorylatable serines at its N terminus (Ser-273, Ser-282, and Ser-302), and the residues' phosphorylation states may alter thick filament structure and function. To examine the effects of cMyBP-C phosphorylation, we generated transgenic mice with cardiac-specific expression of a cMyBP-C in which the three phosphorylation sites were mutated to aspartic acid,...

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Identifiers

PMID: 17075052
DOI: 10.1073/pnas.0607069103
PMCID: PMC1636554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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