Article
Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation.
Circulation - 20 Nov 2007
Nagayama Takahiro, Takimoto Eiki, Sadayappan Sakthivel, Mudd James O, Seidman J G, Robbins Jeffrey, Kass David A
Abstract excerpt
BACKGROUND: Cardiac myosin binding protein-C (cMyBP-C) is a thick-filament protein whose presence and phosphorylation by protein kinase A (PKA) regulates cross-bridge formation and kinetics in isolated myocardium. We tested the influence of cMyBP-C and its PKA-phosphorylation on contraction/relaxation kinetics in intact hearts and revealed its essential role in several classic properties of cardiac function....
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