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Article

Matrix-Targeting Immunotherapy Controls Tumor Growth and Spread by Switching Macrophage Phenotype.

Cancer immunology research - 1 Mar 2020

Deligne Claire, Murdamoothoo Devadarssen, Gammage Anís N, Gschwandtner Martha, Erne William, Loustau Thomas, Marzeda Anna M, Carapito Raphael, Paul Nicodème, Velazquez-Quesada Inés, Mazzier Imogen, Sun Zhen, Orend Gertraud, Midwood Kim S

Abstract excerpt

The interplay between cancer cells and immune cells is a key determinant of tumor survival. Here, we uncovered how tumors exploit the immunomodulatory properties of the extracellular matrix to create a microenvironment that enables their escape from immune surveillance. Using orthotopic grafting of mammary tumor cells in immunocompetent mice and autochthonous models of breast cancer, we discovered how tenascin-C,...

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Source

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Identifiers

PMID: 31941671
DOI: 10.1158/2326-6066.CIR-19-0276
PMCID: PMC7611136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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