Article
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2009
Taimen Pekka, Pfleghaar Katrin, Shimi Takeshi, Möller Dorothee, Ben-Harush Kfir, Erdos Michael R, Adam Stephen A, Herrmann Harald, Medalia Ohad, Collins Francis S, Goldman Anne E, Goldman Robert D
Abstract excerpt
Numerous mutations in the human A-type lamin gene (LMNA) cause the premature aging disease, progeria. Some of these are located in the alpha-helical central rod domain required for the polymerization of the nuclear lamins into higher order structures. Patient cells with a mutation in this domain,...
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