Article

APR-246 & COTI-2 increase chemoradiotherapy sensitivity via ROS-induced DNA damage and ferroptosis in p53 mutant HPV negative head and neck squamous cell carcinoma

2024-12-23

Abstract excerpt

About 80% of patients with HPV negative head and neck squamous cell carcinoma are diagnosed at stage III or IV. In these cases, Surgical resection followed by (chemo-)radiotherapy is the standard treatment for most cases. However, many patients present with unresectable and/or resistant disease and even metastases, limiting therapeutic options. A common molecular defect in these tumours is the deactivation of the...

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Literature Corpus work: 59e36d0c-9d5e-58b1-a81a-d6aaf3966546
DOI: 10.1101/2024.12.23.630069

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