Article
Application of synthetic oligonucleotides to detect DQ beta genes transmission within insulin-dependent diabetes families.
Disease markers - 1 Jan 2000
Toyoda H, Onohara-Toyoda M, Krull J, Vadheim C M, Bickal J C, Riley W J, MacLaren N K, Itakura K, Rotter J I
Abstract excerpt
Class II antigen genes encoded by the major histocompatibility complex region (HLA-D region) in man play an important role in susceptibility to insulin dependent diabetes mellitus (IDDM). Evidence suggests that the DQ subregion within the HLA-D region is more directly responsible for susceptibili...
Topics
- Alleles
- DNA
- Deoxyribonuclease BamHI
- Deoxyribonucleases, Type II Site-Specific
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- Humans
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Pedigree
- Polymorphism, Restriction Fragment Length