Article
Application of synthetic oligonucleotides to detect DQ beta genes transmission within insulin-dependent diabetes families.
Disease markers - 1 Jan 2000
Toyoda H, Onohara-Toyoda M, Krull J, Vadheim C M, Bickal J C, Riley W J, MacLaren N K, Itakura K, Rotter J I
Abstract excerpt
Class II antigen genes encoded by the major histocompatibility complex region (HLA-D region) in man play an important role in susceptibility to insulin dependent diabetes mellitus (IDDM). Evidence suggests that the DQ subregion within the HLA-D region is more directly responsible for susceptibility to IDDM. Therefore, we designed a synthetic oligonucleotide specific for the DQ beta gene to further the...
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