Article
Oligonucleotide dot-blot analysis of HLA-DQ beta alleles associated with multiple sclerosis.
Journal of neuroimmunology - 1 Apr 1991
Sinha A A, Bell R B, Steinman L, McDevitt H O
Abstract excerpt
Oligonucleotide probes were used to investigate the role of DQ beta molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQ beta 1 have been suggested to be critical in disease development, we find that the distribution of sequences corresponding to residues 71-77 is not greater in patients versus controls.
Topics
- Alleles
- Base Sequence
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- Humans
- Molecular Sequence Data
- Multiple Sclerosis
- Oligonucleotide Probes