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Article

Clinical relevance of apolipoprotein E genotyping based on a family history of Alzheimer's disease.

Current Alzheimer research - 1 Jan 2015

Luckhoff Hilmar K, Brand Theresa, van Velden Dawid P, Kidd Martin, Fisher Leslie R, van Rensburg Susan J, Kotze Maritha J

Abstract excerpt

Having a family history of Alzheimer' s disease (AD) may potentiate cumulative risk associated with phenotypic expression of the ε-4 allele of the apolipoprotein E (APOE) gene. In this study, we compared the genotype distribution and allele frequencies of APOE ε-2 (rs7412) and ε -4 (rs429358) in 537 South African individuals participating in a chronic disease screening program, in order to establish whether AD...

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Source

Identifiers

PMID: 25731628
DOI: 10.2174/1567205012666150302154354

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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