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How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer's disease risk? A novel integrative model.

Alzheimer's research & therapy - 27 Jan 2023

de Frutos Lucas Jaisalmer, Sewell Kelsey R, García-Colomo Alejandra, Markovic Shaun, Erickson Kirk I, Brown Belinda M

Abstract excerpt

BACKGROUND: Wide evidence suggests that physical activity (PA) confers protection against Alzheimer's disease (AD). On the other hand, the apolipoprotein E gene (APOE) ε4 allele represents the greatest genetic risk factor for developing AD. Extensive research has been conducted to determine whether frequent PA can mitigate the increased AD risk associated with APOE ε4. However, thus far, these attempts have...

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PMID: 36707869
DOI: 10.1186/s13195-023-01170-4
PMCID: PMC9881295

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