Article
Frequencies of Gag-restricted T-cell escape "footprints" differ across HIV-1 clades A1 and D chronically infected Ugandans irrespective of host HLA B alleles.
Vaccine - 30 Mar 2015
Serwanga Jennifer, Nakiboneka Ritah, Mugaba Susan, Magambo Brian, Ndembi Nicaise, Gotch Frances, Kaleebu Pontiano
Abstract excerpt
OBJECTIVE(S): We evaluated relationships between critical Gag T-cell escape mutations and concomitant T-cell responses to determine whether HLA-restricted Gag mutations that confer protection, occur at similar rates in a population infected with mixed HIV-1 clades A1 and D viruses. METHODS: Assessment of Gag selective pressure, and adaptive T-cell functions to KAFSPEVIPMF (KF11), ISPRTLNAW (ISW9) and TSTLQEQIGW...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.