Article
Host HLA B*allele-associated multi-clade Gag T-cell recognition correlates with slow HIV-1 disease progression in antiretroviral therapy-naïve Ugandans.
PloS one - 1 Jan 2009
Serwanga Jennifer, Shafer Leigh Anne, Pimego Edward, Auma Betty, Watera Christine, Rowland Samantha, Yirrell David, Pala Pietro, Grosskurth Heiner, Whitworth Jimmy, Gotch Frances, Kaleebu Pontiano
Abstract excerpt
BACKGROUND: Some HIV infected individuals remain asymptomatic for protracted periods of time in the absence of antiretroviral therapy (ART). Virological control, CD4 T cell loss and HIV-specific responses are some of the key interrelated determinants of HIV-1 disease progression. In this study, possible interactions between viral load, CD4 T cell slopes, host genetics and HIV-specific IFN-gamma responses were...
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