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Article

Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015

Giles Joanna L, Choy Ernest, van den Berg Carmen, Morgan B Paul, Harris Claire L

Abstract excerpt

Complement is implicated in the pathogenesis of rheumatoid arthritis (RA); elevated levels of complement activation products have been measured in plasma, synovial fluid, and synovial tissues of patients. Complement polymorphisms are associated with RA in genome-wide association studies. Coding-region polymorphisms may directly impact protein activity; indeed, we have shown that complement polymorphisms affecting...

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Identifiers

PMID: 25725109
DOI: 10.4049/jimmunol.1402956
PMCID: PMC4367161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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