Article
Polymorphism of the complement 5 gene and cardiovascular outcome in patients with atherosclerosis.
European journal of clinical investigation - 1 Sept 2012
Hoke Matthias, Speidl Walter, Schillinger Martin, Minar Erich, Zehetmayer Sonja, Schönherr Michael, Wagner Oswald, Mannhalter Christine
Abstract excerpt
BACKGROUND: Humoral mediators of inflammation, in particular the complement system, have been described to play an important role in atherogenesis. Previously, we found a single-nucleotide polymorphism (SNP) in the complement 5 gene (C5 rs17611, A>G) independently associated with stroke. Up to now, the impact of C5 rs17611 on the progression of atherosclerosis and cardiovascular outcome in patients with...
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