Article
A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.
PLoS medicine - 1 Sept 2007
Kurreeman Fina A S, Padyukov Leonid, Marques Rute B, Schrodi Steven J, Seddighzadeh Maria, Stoeken-Rijsbergen Gerrie, van der Helm-van Mil Annette H M, Allaart Cornelia F, Verduyn Willem, Houwing-Duistermaat Jeanine, Alfredsson Lars, Begovich Ann B, Klareskog Lars, Huizinga Tom W J, Toes Rene E M
Abstract excerpt
BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting approximately 1% of the population. The disease results from the interplay between an individual's genetic background and unknown environmental triggers. Although human leukocyte antigens (HLAs) account for approximately 30% of the heritable risk, the identities of non-HLA genes explaining the remainder of the genetic component are...
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