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Article

Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.

Clinical and experimental immunology - 1 Jul 2013

Trouw L A, Daha N, Kurreeman F A S, Böhringer S, Goulielmos G N, Westra H J, Zhernakova A, Franke L, Stahl E A, Levarht E W N, Stoeken-Rijsbergen G, Verduijn W, Roos A, Li Y, Houwing-Duistermaat J J, Huizinga T W J, Toes R E M

Abstract excerpt

Rodent models for arthritis implicate a role for complement in disease development and progression. In humans, complement deposition has been observed in inflamed synovia of rheumatoid arthritis (RA) patients. In this study we analysed whether genetic variants of complement component C1q predispose to RA. We genotyped single nucleotide polymorphisms (SNPs) in and around the C1q genes, C1qA, C1qB and C1qC, in a...

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Identifiers

PMID: 23607884
DOI: 10.1111/cei.12097
PMCID: PMC3694537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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