Article
Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.
Clinical and experimental immunology - 1 Jul 2013
Trouw L A, Daha N, Kurreeman F A S, Böhringer S, Goulielmos G N, Westra H J, Zhernakova A, Franke L, Stahl E A, Levarht E W N, Stoeken-Rijsbergen G, Verduijn W, Roos A, Li Y, Houwing-Duistermaat J J, Huizinga T W J, Toes R E M
Abstract excerpt
Rodent models for arthritis implicate a role for complement in disease development and progression. In humans, complement deposition has been observed in inflamed synovia of rheumatoid arthritis (RA) patients. In this study we analysed whether genetic variants of complement component C1q predispo...
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