Article

Experimental arthritis in CC chemokine receptor 2–null mice closely mimics severe human rheumatoid arthritis

2004-03-15

Abstract excerpt

The prevailing paradigm is that in human rheumatoid arthritis (RA), the accumulation of monocytes and T cells in the joint, mediated in part by such CC chemokine receptors (CCRs) as CCR2 and CCR5, respectively, plays a central role in disease pathogenesis. To further validate this paradigm, we conducted proof-of-principle studies and tested the hypothesis that gene inactivation of Ccr2 or Ccr5 will ameliorate expe...

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Literature Corpus work: caaf0adc-33d7-5e5f-8b29-6913a0f47517
DOI: 10.1172/jci200420126

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