Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Expanding Role for Interleukin-1 Blockade from Gout to Cancer

1 Jan 2014

Abstract excerpt

There is an expanding role for interleukin (IL)-1 in diseases from gout to cancer. More than any other cytokine family, the IL-1 family is closely linked to innate inflammatory and immune responses. This linkage is because the cytoplasmic segment of all members of the IL-1 family of receptors contains a domain, which is highly homologous to the cytoplasmic domains of all toll-like receptors (TLRs). This domain,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gout, Hyperuricemia, Uric Acid
Share to IL-33, ST2, and ILC Pathways
Share to Inflammasome and immune disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25549233
DOI: 10.2119/molmed.2014.00232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Expanding Role for Interleukin-1 Blockade from Gout to CancerPMID 25549233Read ↗

Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and DiseaseSemantic proximity Read ↗

Tuning inflammation and immunity by the negative regulators IL ‐1R2 and IL ‐1R8Semantic proximity Read ↗

Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signalingSemantic proximity Read ↗

Interleukin-1 and interleukin-1 antagonismSemantic proximity Read ↗

Interleukin-1 and interleukin-1 antagonismSemantic proximity Read ↗

The IL-1 Family and Its Role in AtherosclerosisSemantic proximity Read ↗

[Update in interleukin-1 inhibition].Semantic proximity Read ↗

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseasesSemantic proximity Read ↗

[Interleukin-1, inflammasome and autoinflammatory diseases].Semantic proximity Read ↗

Biologic activities of IL-1 and its role in human diseaseSemantic proximity Read ↗

IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILCSemantic proximity Read ↗

Targeting TLR/IL-1R Signalling in Human DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.