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Article

IRF4, MC1R and TYR genes are risk factors for actinic keratosis independent of skin color.

Human molecular genetics - 1 Jun 2015

Jacobs Leonie C, Liu Fan, Pardo Luba M, Hofman Albert, Uitterlinden André G, Kayser Manfred, Nijsten Tamar

Abstract excerpt

Actinic keratosis (AK) is a pre-malignant skin disease, highly prevalent in elderly Europeans. This study investigates genetic susceptibility to AK with a genome-wide association study (GWAS). A full body skin examination was performed in 3194 elderly individuals from the Rotterdam Study (RS) of exclusive north-western European origin (aged 51-99 years, 45% male). Physicians graded the number of AK into four...

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Source

Identifiers

PMID: 25724930
DOI: 10.1093/hmg/ddv076

Genes

TYR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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