Article
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.
Nature genetics - 1 Jul 2008
Gudbjartsson Daniel F, Sulem Patrick, Stacey Simon N, Goldstein Alisa M, Rafnar Thorunn, Sigurgeirsson Bardur, Benediktsdottir Kristrun R, Thorisdottir Kristin, Ragnarsson Rafn, Sveinsdottir Steinunn G, Magnusson Veronica, Lindblom Annika, Kostulas Konstantinos, Botella-Estrada Rafael, Soriano Virtudes, Juberías Pablo, Grasa Matilde, Saez Berta, Andres Raquel, Scherer Dominique, Rudnai Peter, Gurzau Eugene, Koppova Kvetoslava, Kiemeney Lambertus A, Jakobsdottir Margret, Steinberg Stacy, Helgason Agnar, Gretarsdottir Solveig, Tucker Margaret A, Mayordomo José I, Nagore Eduardo, Kumar Rajiv, Hansson Johan, Olafsson Jon H, Gulcher Jeffrey, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
Fair color increases risk of cutaneous melanoma (CM) and basal cell carcinoma (BCC). Recent genome-wide association studies have identified variants affecting hair, eye and skin pigmentation in Europeans. Here, we assess the effect of these variants on risk of CM and BCC in European populations comprising 2,121 individuals with CM, 2,163 individuals with BCC and over 40,000 controls. A haplotype near ASIP, known...
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