Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pigmentation-Independent Susceptibility Loci for Actinic Keratosis Highlighted by Compound Heterozygosity Analysis.

The Journal of investigative dermatology - 1 Jan 2017

Zhong Kaiyin, Verkouteren Joris A C, Jacobs Leonie C, Uitterlinden Andre G, Hofman Albert, Liu Fan, Nijsten Tamar, Kayser Manfred

Abstract excerpt

Actinic keratosis (AK) is a skin disease frequently found in European elderly, and it represents the precursor of cutaneous squamous cell carcinoma. Our recent genome-wide association study highlighted DNA variants in two pigmentation genes, IRF4 and MC1R, that confer AK risk in Europeans. Here, we performed a genome-wide search for relaxed forms of compound heterozygosity in association with AK using our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Databases, Factual

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Regulatory Factors

Share to Multivariate Analysis

Share to Netherlands

Share to Precancerous Conditions

Share to Skin Neoplasms

Share to Skin Pigmentation

Source

Identifiers

PMID: 27646882
DOI: 10.1016/j.jid.2016.09.007

Genes

GSTA2
KCNK17
KCNK5
KCNQ5
KHDC1
PAQR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pigmentation-Independent Susceptibility Loci for Actinic Keratosis Highlighted by Compound Heterozygosity Analysis.PMID 27646882Read ↗

Genome-wide association study of actinic keratosis identifies new susceptibility loci implicated in pigmentation and immune regulation pathways.Semantic proximity Read ↗

IRF4, MC1R and TYR genes are risk factors for actinic keratosis independent of skin color.Semantic proximity Read ↗

DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity.Semantic proximity Read ↗

Skin Phototype and Disease: A Comprehensive Genetic Approach to Pigmentary Traits Pleiotropy Using PRS in the GCAT Cohort.Semantic proximity Read ↗

Skin Phototype and Disease. A Comprehensive Genetic Approach to Pigmentary Traits Pleiotropy using PRS in the GCAT CohortSemantic proximity Read ↗

Functional Annotations of Single-Nucleotide Polymorphism (SNP)-Based and Gene-Based Genome-Wide Association Studies Show Genes Affecting Keratitis Susceptibility.Semantic proximity Read ↗

Comprehensive Evaluation of the Genetic Basis of Keratoconus: New Perspectives for Clinical Translation.Semantic proximity Read ↗

Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.Semantic proximity Read ↗

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots.Semantic proximity Read ↗

Genetic associations for keratoconus: a systematic review and meta-analysis.Semantic proximity Read ↗

The Genomic Landscape of Actinic Keratosis.Semantic proximity Read ↗

Association of Novel Loci With Keratoconus Susceptibility in a Chinese Genome-Wide Association Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.