Article
An Unexpectedly Complex Architecture for Skin Pigmentation in Africans.
Cell - 30 Nov 2017
Martin Alicia R, Lin Meng, Granka Julie M, Myrick Justin W, Liu Xiaomin, Sockell Alexandra, Atkinson Elizabeth G, Werely Cedric J, Möller Marlo, Sandhu Manjinder S, Kingsley David M, Hoal Eileen G, Liu Xiao, Daly Mark J, Feldman Marcus W, Gignoux Christopher R, Bustamante Carlos D, Henn Brenna M
Abstract excerpt
Approximately 15 genes have been directly associated with skin pigmentation variation in humans, leading to its characterization as a relatively simple trait. However, by assembling a global survey of quantitative skin pigmentation phenotypes, we demonstrate that pigmentation is more complex than previously assumed, with genetic architecture varying by latitude. We investigate polygenicity in the KhoeSan...
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