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Article

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots.

The Journal of investigative dermatology - 1 Jul 2015

Jacobs Leonie C, Hamer Merel A, Gunn David A, Deelen Joris, Lall Jaspal S, van Heemst Diana, Uh Hae-Won, Hofman Albert, Uitterlinden André G, Griffiths Christopher E M, Beekman Marian, Slagboom P Eline, Kayser Manfred, Liu Fan, Nijsten Tamar

Abstract excerpt

Facial pigmented spots are a common skin aging feature, but genetic predisposition has yet to be thoroughly investigated. We conducted a genome-wide association study for pigmented spots in 2,844 Dutch Europeans from the Rotterdam Study (mean age: 66.9±8.0 years; 47% male). Using semi-automated image analysis of high-resolution digital facial photographs, facial pigmented spots were quantified as the percentage...

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Source

Identifiers

PMID: 25705849
DOI: 10.1038/jid.2015.62

Genes

ASIP
BNC2
RALY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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