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Article

Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis.

Journal of molecular biology - 8 May 2015

Epling Leslie B, Grace Christy R, Lowe Brandon R, Partridge Janet F, Enemark Eric J

Abstract excerpt

The DEAD-box RNA helicase DDX3X is frequently mutated in pediatric medulloblastoma. We dissect how these mutants affect DDX3X function with structural, biochemical, and genetic experiments. We identify an N-terminal extension ("ATP-binding loop", ABL) that is critical for the stimulation of ATP hydrolysis by RNA. We present crystal structures suggesting that the ABL interacts dynamically with ATP and confirming...

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Identifiers

PMID: 25724843
DOI: 10.1016/j.jmb.2015.02.015
PMCID: PMC4402148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis.PMID 25724843Read ↗

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