Article
DDX3X is a Cl--sensitive RNA helicase.
Science signaling - 24 Mar 2026
Rosa E Silva Ivan, do Prado Paula F V, Benevenutti Felipe Z, de Oliveira Renata R, Passos Aline R, Canateli Camila, Messias Isabelly G, Trindade Daniel M, Bortot Leandro O, Guerra João V S, Hancio Thaís, Sforça Mauricio L, Nascimento Andrey F Z, Mercaldi Gustavo F, Pereira José G C, Fonseca Matheus C, de Oliveira Paulo S L, de Carvalho Murilo, Smetana Juliana H C, Krepischi Ana C V, Franchini Kleber G, de Oliveira Juliana F
Abstract excerpt
Cl- homeostasis is pivotal during neurodevelopment and in multiple processes in mature neurons, and its disruption is implicated in several neurodevelopmental disorders. Here, we investigated the role of Cl- in regulating DDX3X, an ATP-dependent RNA helicase that is associated with a neurodevelopmental disorder and is involved in stress granule assembly through biomolecular condensation. Cl- directly interacted...
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