Article
Analog sensitive chemical inhibition of the DEAD-box protein DDX3.
Protein science : a publication of the Protein Society - 1 Mar 2016
Floor Stephen N, Barkovich Krister J, Condon Kendall J, Shokat Kevan M, Doudna Jennifer A
Abstract excerpt
Proper maintenance of RNA structure and dynamics is essential to maintain cellular health. Multiple families of RNA chaperones exist in cells to modulate RNA structure, RNA-protein complexes, and RNA granules. The largest of these families is the DEAD-box proteins, named after their catalytic Asp-Glu-Ala-Asp motif. The human DEAD-box protein DDX3 is implicated in diverse biological processes including translation...
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