Article
Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo.
The Journal of investigative dermatology - 1 Nov 2014
Wu Xuesong, Schulte Brian C, Zhou Youwen, Haribhai Dipica, Mackinnon Alexander C, Plaza Jose A, Williams Calvin B, Hwang Sam T
Abstract excerpt
Macrophages have key roles in tumor development and invasion in several human cancers, but little is known about their pathogenic role in cutaneous T-cell lymphoma (CTCL). Herein, we used PCR arrays to profile the expression of inflammatory cytokines in 12 patients with mycosis fungoides (MF), the most common variant of CTCL. Compared with normal controls, MF skin displayed increased mRNA levels of...
Topics
- Animals
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Bone Marrow Cells
- Cell Line, Tumor
- Clodronic Acid
- Cytokines
- Disease Models, Animal
- Humans
- Inflammation
- Liposomes
- Lymphoma, T-Cell, Cutaneous
- Macrophages