Article
Obesity increases inflammation and impairs lymphatic function in a mouse model of lymphedema.
American journal of physiology. Heart and circulatory physiology - 15 Jul 2014
Savetsky Ira L, Torrisi Jeremy S, Cuzzone Daniel A, Ghanta Swapna, Albano Nicholas J, Gardenier Jason C, Joseph Walter J, Mehrara Babak J
Abstract excerpt
Although obesity is a major clinical risk factor for lymphedema, the mechanisms that regulate this effect remain unknown. Recent reports have demonstrated that obesity is associated with acquired lymphatic dysfunction. The purpose of this study was to determine how obesity-induced lymphatic dysfunction modulates the pathological effects of lymphatic injury in a mouse model. We used a diet-induced model of obesity...
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