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Article

Escherichia coli rpoB mutants have increased evolvability in proportion to their fitness defects.

Molecular biology and evolution - 1 Jun 2010

Barrick Jeffrey E, Kauth Mark R, Strelioff Christopher C, Lenski Richard E

Abstract excerpt

Evolvability is the capacity of an organism or population for generating descendants with increased fitness. Simulations and comparative studies have shown that evolvability can vary among individuals and identified characteristics of genetic architectures that can promote evolvability. However,...

Topics

DNA-Directed RNA Polymerases
Escherichia coli
Escherichia coli Proteins
Evolution, Molecular
Genetic Fitness
Genetic Markers
Linear Models
Models, Genetic
Mutation
Stochastic Processes
Systems Biology

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Identifiers

PMID: 20106907
DOI: 10.1093/molbev/msq024
PMCID: PMC2872623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-20106907-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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