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Article

NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice.

Nature communications - 16 Nov 2024

Wang Jie, Zhao Rui, Xu Sha, Zhou Xiang-Yu, Cai Ke, Chen Yu-Ling, Zhou Ze-Yu, Sun Xin, Shi Yan, Wang Feng, Gui Yong-Hao, Tao Hui, Zhao Jian-Yuan

Abstract excerpt

Notch signaling activation drives an endothelial-to-mesenchymal transition (EndMT) critical for heart development, although evidence suggests that the reprogramming of endothelial cell metabolism can regulate endothelial function independent of canonical cell signaling. Herein, we investigated the crosstalk between Notch signaling and metabolic reprogramming in the EndMT process. Biochemically, we find that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39550366
DOI: 10.1038/s41467-024-54407-7
PMCID: PMC11569218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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