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Article

<i>TERT</i> promoter mutations and telomerase reactivation in urothelial cancer

6 Feb 2015

Abstract excerpt

Reactivation of telomerase, the chromosome end-replicating enzyme, drives human cell immortality and cancer. Point mutations in the telomerase reverse transcriptase (TERT) gene promoter occur at high frequency in multiple cancers, including urothelial cancer (UC), but their effect on telomerase function has been unclear. In a study of 23 human UC cell lines, we show that these promoter mutations correlate with...

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PMID: 25722414
DOI: 10.1126/science.1260200

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