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Article

TERT promoter mutations and methylation for telomerase activation in urothelial carcinomas: New mechanistic insights and clinical significance.

Frontiers in immunology - 1 Jan 2022

Liu Tiantian, Li Shihong, Xia Chuanyou, Xu Dawei

Abstract excerpt

Telomerase, an RNA-dependent DNA polymerase synthesizing telomeric TTAGGG sequences, is primarily silent in normal human urothelial cells (NHUCs), but widely activated in urothelial cell-derived carcinomas or urothelial carcinomas (UCs) including UC of the bladder (UCB) and upper track UC (UTUC). Telomerase activation for telomere maintenance is required for the UC development and progression, and the key...

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Share to Bladder and Urothelial Cancer Treatments
Share to Carcinoma, Transitional Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Telomeres, Telomerase, and Senescence

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Source

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Identifiers

PMID: 36713366
DOI: 10.3389/fimmu.2022.1071390
PMCID: PMC9877314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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