Article
Involvement of matrix metalloproteinases in chronic Q fever.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Jul 2017
Jansen A F M, Schoffelen T, Textoris J, Mege J L, Bleeker-Rovers C P, Roest H I J, Wever P C, Joosten L A B, Netea M G, van de Vosse E, van Deuren M
Abstract excerpt
OBJECTIVES: Chronic Q fever is a persistent infection with the intracellular Gram-negative bacterium Coxiella burnetii, which can lead to complications of infected aneurysms. Matrix metalloproteinases (MMPs) cleave extracellular matrix and are involved in infections as well as aneurysms. We aimed to study the role of MMPs in the pathogenesis of chronic Q fever. METHODS: We investigated gene expression of MMPs...
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