Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications.

doi:10.1371/journal.pone.0318134

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Article

Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications.

PloS one - 1 Jan 2025

Huang Guoni, Cheng Jing, Liu Wenfeng, Yang Tong, Ye Tao, Zhang Qian, Chen Qi, Xu Yuzhong

Abstract excerpt

OBJECTIVES: This case-control study aims to clarify the impact of single nucleotide polymorphisms (SNPs) within the P2X7 gene on susceptibility to type 2 diabetes mellitus (T2DM) and to evaluate their association with diabetic complications. METHODS: This study is comprised with 200 T2DM cases and 200 healthy controls. Seven candidate SNP loci were screened, and TaqMan-MGB real-time PCR technology was used to...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 2
Receptors, Purinergic P2X7
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Middle Aged

Case-Control Studies

Gene Frequency

Diabetes Complications

Aged

Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 39869622
DOI: 10.1371/journal.pone.0318134
PMCID: PMC11771865

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