Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.

doi:10.1038/nm.2710

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Article

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.

Nature medicine - 25 Mar 2012

Sorge Robert E, Trang Tuan, Dorfman Ruslan, Smith Shad B, Beggs Simon, Ritchie Jennifer, Austin Jean-Sebastien, Zaykin Dmitri V, Vander Meulen Heather, Costigan Michael, Herbert Teri A, Yarkoni-Abitbul Merav, Tichauer David, Livneh Jessica, Gershon Edith, Zheng Ming, Tan Keith, John Sally L, Slade Gary D, Jordan Joanne, Woolf Clifford J, Peltz Gary, Maixner William, Diatchenko Luda, Seltzer Ze'ev, Salter Michael W, Mogil Jeffrey S

Abstract excerpt

Chronic pain is highly variable between individuals, as is the response to analgesics. Although much of the variability in chronic pain and analgesic response is heritable, an understanding of the genetic determinants underlying this variability is rudimentary. Here we show that variation within the coding sequence of the gene encoding the P2X7 receptor (P2X7R) affects chronic pain sensitivity in both mice and...

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Identifiers

PMID: 22447075
DOI: 10.1038/nm.2710
PMCID: PMC3350463

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