Unearthing novel mutations and genetic variation in drug sensitive and resistant isolates of Mycobacterium tuberculosis through whole genome sequencing: A study from eastern Uttar Pradesh, India.

Abstract excerpt

PURPOSE: Drug-resistant tuberculosis (DR-TB) presents a formidable public health challenge worldwide. Therefore, this study was conducted to elucidate the complete genetic profiles of drug-sensitive (DS), and drug-resistant TB isolates using Whole Genome Sequencing (WGS). METHODS: The study includes a set of sputum specimens containing five DS-TB, multidrug-resistant tuberculosis (MDR-TB) and extensively...

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