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[Generation and study of the strains of streptomycetes--heterologous hosts for the production of moenomycin].

Genetika - 1 Apr 2014

Lopatniuk M M, Ostash B E, Luzheckiĭ A N, Walker S, Fedorenko V A

Abstract excerpt

In this paper, we report the generation of a number of novel heterologous streptomycete hosts producing nosokomycin A2 (one of the members of Mm family) and determine their potential for antibiotic production. The rpoB point mutation in the model strain of Streptomyces coelicolor (strain M1152) significantly improved nosokomycin A2 production compared to parental strains (M145 and M512), while double rpoBrpsL...

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PMID: 25715443

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