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Article

The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2).

Microbiology (Reading, England) - 1 Oct 2017

Som Nicolle F, Heine Daniel, Holmes Neil, Knowles Felicity, Chandra Govind, Seipke Ryan F, Hoskisson Paul A, Wilkinson Barrie, Hutchings Matthew I

Abstract excerpt

MtrAB is a highly conserved two-component system implicated in the regulation of cell division in the Actinobacteria. It coordinates DNA replication with cell division in the unicellular Mycobacterium tuberculosis and links antibiotic production to sporulation in the filamentous Streptomyces venezuelae. Chloramphenicol biosynthesis is directly regulated by MtrA in S. venezuelae and deletion of mtrB constitutively...

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Identifiers

PMID: 28884676
DOI: 10.1099/mic.0.000524
PMCID: PMC5845573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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