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Genetically engineered Streptomyces viridosporus ATCC 14672 strains for the discovery of novel moenomycins.

Scientific reports - 10 Mar 2026

Ostash Bohdan, Makitrynskyy Roman, Fedchyshyn Mariana, Luzhetskyy Andriy, Walker Suzanne, Fedorenko Victor

Abstract excerpt

Streptomyces viridosporus (formerly ghanaensis) ATCC14672 is the best-studied producer of moenomycins, a family of phosphoglycolipid natural products directly inhibiting peptidoglycan glycosyltransferases. The uniqueness of moenomycins, in terms of structure and mode of action, and their extreme potency against several Gram-positive pathogens (including vancomycin- and methicillin-resistant cocci), are their...

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Anti-Bacterial Agents
Genetic Engineering
Mutation
Oligosaccharides
Streptomyces

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PMID: 41807664
DOI: 10.1038/s41598-026-43988-6
PMCID: PMC13096315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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