Article
Refining antipsychotic treatment strategies in schizophrenia: discovery of genetic biomarkers for enhanced drug response prediction.
Molecular psychiatry - 1 Jun 2025
Chen Luan, Huai Cong, Song Chuanfu, Wu Shaochang, Xu Yong, Yi Zhenghui, Tang Jinsong, Fan Lingzi, Wu Xuming, Ge Zhenhua, Liu Chuanxin, Jiang Deguo, Weng Saizheng, Wang Guoqiang, Zhang Xinfeng, Zhao Xudong, Shen Lu, Zhang Na, Wu Hao, Wang Yongzhi, Guo Zhenglin, Zhang Suli, Jiang Bixuan, Zhou Wei, Ma Jingsong, Li Mo, Chu Yunpeng, Zhou Chenxi, Lv Qinyu, Xu Qingqing, Zhu Wenli, Zhang Yan, Lian Weibin, Liu Sha, Li Xinrong, Gao Songyin, Liu Aihong, He Lei, Yang Zhenzhen, Dai Bojian, Ye Jiaen, Lin Ruiqian, Lu Yana, Yan Qi, Hu Yalan, Xing Qinghe, Huang Hailiang, Qin Shengying
Abstract excerpt
Schizophrenia (SCZ) is a severe mental disorder affecting around 1% of individuals worldwide. The variability in response to antipsychotic drugs (APDs) among SCZ patients presents a significant challenge for clinicians in determining the most effective medication. In this study, we investigated the biological markers and established a predictive model for APD response based on a large-scale genome-wide...
Read the complete abstract on PubMedTopics
- Adult
- Female
- Humans