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Article

No contribution of the ABCB11 p.444A polymorphism in Japanese patients with drug-induced cholestasis.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2015

Kagawa Tatehiro, Hirose Shunji, Arase Yoshitaka, Oka Akira, Anzai Kazuya, Tsuruya Kota, Shiraishi Koichi, Orii Reiko, Ieda Satsuki, Nakazawa Takahide, Tomita Kengo, Hokari Ryota, Miura Soichiro, Ebinuma Hirotoshi, Saito Hidetsugu, Kitamura Tsuneo, Horie Yoshinori, Okuse Chiaki, Wasada Mitsuru, Inoko Hidetoshi, Tohkin Masahiro, Saito Yoshiro, Maekawa Keiko, Takikawa Hajime, Mine Tetsuya

Abstract excerpt

European studies have revealed that the ABCB11 c.1331T>C (V444A) polymorphism (rs2287622) C-allele frequency is higher among patients with drug-induced cholestasis. Given the low incidence of this disease, however, this association has not been sufficiently elucidated. We aimed to investigate the significance of this polymorphism in Japanese patients. We determined ABCB11 V444A polymorphism frequencies and HLA...

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Source

Identifiers

PMID: 25713208
DOI: 10.1124/dmd.114.061325

Genes

ABCB11

Variants

rs2287622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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