Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis.

Abstract excerpt

INTRODUCTION: Drug-induced cholestasis, intrahepatic cholestasis of pregnancy and viral hepatitis are acquired forms of liver disease. Cholestasis is a pathophysiologic state with impaired bile formation and subsequent accumulation of bile salts in hepatocytes. The bile salt export pump (BSEP) (ABCB11) is the key export system for bile salts from hepatocytes. AREAS COVERED: This article provides an introduction...

Topics

• ATP Binding Cassette Transporter, Subfamily B
• Bile Acids and Salts
• Biological Transport
• Cholestasis, Intrahepatic
• Clinical Trials as Topic
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genetic Variation