Article
Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies.
Pharmacogenomics - 1 Jan 2015
Fan Junwei, Zhang Xiaoqing, Ren Lei, Chen Dawei, Wu Shaohan, Guo Feng, Qin Shengying, Wang Zhaowen, Lin Zhong, Xing Tonghai, Sun Xing, Peng Zhihai
Abstract excerpt
AIM: This study evaluated the relationships between IL-18 polymorphisms and tacrolimus elimination in Chinese liver transplant patients. PATIENTS & METHODS: Eighty-four liver transplant patients from Shanghai (training set) and 50 patients from Shandong (validating set) were inculded. IL-18 polymorphisms (rs5744247, rs7106524, rs549908, rs187238 and rs1946518) and CYP3A5 were genotyped. RESULTS: In...