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Article

Influence of TLR4 rs1927907 locus polymorphisms on tacrolimus pharmacokinetics in the early stage after liver transplantation.

European journal of clinical pharmacology - 1 Aug 2014

Wang Zhaowen, Wu Shaohan, Chen Dawei, Guo Feng, Zhong Lin, Fan Junwei, Peng Zhihai

Abstract excerpt

PURPOSE: The aim of this study was to assess the potential influence of single nucleotide polymorphisms (SNPs) in the TLR4 gene on tacrolimus pharmacokinetics in the early stage after liver transplantation. METHODS: A total of 96 liver transplant patients receiving tacrolimus-based immunosuppressive regimens were enrolled in this study. The SNPs of CYP3A5 rs776746 and TLR4 rs1927907 were genotyped in both donors...

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Source

Identifiers

PMID: 24820765
DOI: 10.1007/s00228-014-1673-2

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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