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Article

Association between interleukin-18 promoter variants and tacrolimus pharmacokinetics in Chinese renal transplant patients.

European journal of clinical pharmacology - 1 Feb 2015

Xing Jiazhen, Zhang Xiaoqing, Fan Junwei, Shen Bin, Men Tongyi, Wang Jianning

Abstract excerpt

PURPOSE: Interleukin 18 (IL-18) is a potent proinflammatory cytokine thought to down-regulate cytochrome P450 (CYP) enzyme activities. This study aimed to assess the potential influence of two functional single nucleotide polymorphisms (SNPs) in the IL-18 promoter region on the tacrolimus pharmacokinetics in Chinese renal transplant patients. METHODS: We enrolled 96 renal allograft recipients receiving...

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Source

Identifiers

PMID: 25487141
DOI: 10.1007/s00228-014-1785-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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