Article
Association of donor small ubiquitin-like modifier 4 rs237025 genetic variant with tacrolimus elimination in the early period after liver transplantation.
Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2018
Zhang Tao, Liu Yuan, Zeng Rong, Ling Qi, Wen Peihao, Fan Junwei, Peng Zhihai
Abstract excerpt
BACKGROUNDS & AIMS: Individualized tacrolimus treatment can improve drug safety and efficacy. In this study, we aimed to investigate the association of donor and recipient small ubiquitin-like modifier 4 (SUMO4) rs237025 polymorphisms with tacrolimus elimination and the potential mechanism. METHODS: A total of 297 liver transplant patients were enrolled in the study. CYP3A5 rs776746 and SUMO4 rs237025 were...
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