Article
Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy.
Medicine - 1 Mar 2018
Liu Xin, Hong Xiumei, Tsai Hui-Ju, Mestan Karen K, Shi Min, Kefi Amira, Hao Ke, Chen Qi, Wang Guoying, Caruso Deanna, Geng Hua, Gao Yufeng, He Jianlin, Kumar Rajesh, Wang Hongjian, Yu Yunxian, Bartell Tami, Tan Xiao-Di, Schleimer Robert P, Weeks Daniel E, Pongracic Jacqueline A, Wang Xiaobin
Abstract excerpt
Previous genetic studies of food allergy (FA) have mainly focused on inherited genotypic effects. The role of parental genotypic effects remains largely unexplored. Leveraging existing genome-wide association study (GWAS) data generated from the Chicago Food Allergy Study, we examined maternal genotypic and parent-of-origin (PO) effects using multinomial likelihood ratio tests in 588 complete and incomplete...
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