Article
Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Feb 2017
Martino D J, Ashley S, Koplin J, Ellis J, Saffery R, Dharmage S C, Gurrin L, Matheson M C, Kalb B, Marenholz I, Beyer K, Lee Y-A, Hong X, Wang X, Vukcevic D, Motyer A, Leslie S, Allen K J, Ferreira M A R
Abstract excerpt
BACKGROUND: Genetic variants for IgE-mediated peanut allergy are yet to be fully characterized and to date only one genomewide association study (GWAS) has been published. OBJECTIVE: To identify genetic variants associated with challenge-proven peanut allergy. METHODS: We carried out a GWAS comparing 73 infants with challenge-proven IgE-mediated peanut allergy against 148 non-allergic infants (all ~ 1 year old)....
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