Article
A modified Lynch syndrome screening algorithm in colon cancer: BRAF immunohistochemistry is efficacious and cost beneficial.
American journal of clinical pathology - 1 Mar 2015
Roth Rachel M, Hampel Heather, Arnold Christina A, Yearsley Martha M, Marsh William L, Frankel Wendy L
Abstract excerpt
OBJECTIVES: Somatic BRAF mutation in colon cancer essentially excludes Lynch syndrome. We compared BRAF V600E immunohistochemistry (IHC) with BRAF mutation in core, biopsy, and whole-section slides to determine whether IHC is similar and to assess the cost-benefit of IHC. METHODS: Resection cases (2009-2013) with absent MLH1 and PMS2 and prior BRAF mutation polymerase chain reaction results were chosen (n = 57)....
Topics
- Adult
- Aged
- Aged, 80 and over
- Algorithms
- Amino Acid Substitution
- Biopsy
- Colonic Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Cost-Benefit Analysis
- DNA Mutational Analysis
- Education, Medical, Continuing
- Female
- Humans