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Adenosine Monophosphate-activated Protein Kinase Regulates Interleukin-1β Expression and Glial Glutamate Transporter Function in Rodents with Neuropathic Pain.

Anesthesiology - 1 Jun 2015

Maixner Dylan W, Yan Xisheng, Gao Mei, Yadav Ruchi, Weng Han-Rong

Abstract excerpt

BACKGROUND: Neuroinflammation and dysfunctional glial glutamate transporters (GTs) in the spinal dorsal horn are implicated in the genesis of neuropathic pain. The authors determined whether adenosine monophosphate-activated protein kinase (AMPK) in the spinal dorsal horn regulates these processes in rodents with neuropathic pain. METHODS: Hind paw withdrawal responses to radiant heat and mechanical stimuli were...

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PMID: 25710409
DOI: 10.1097/ALN.0000000000000619
PMCID: PMC4439367

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